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Evidence that industry may be better than academia at prospective trial registration, though improvements are required

In 2005, the International Committee of Medical Journal Editors (ICMJE) introduced mandatory trial registration guidelines and member journals require prospective registration of trials prior to patient enrolment as a condition … Continue Reading Evidence that industry may be better than academia at prospective trial registration, though improvements are required

Comparison of serious adverse events posted at ClinicalTrials.gov and published in corresponding journal articles

A study published in BMC Medicine this week assessed the consistency between the reporting of serious adverse events (SAEs) posted at ClinicalTrials.gov and those published in corresponding journal articles. Key findings … Continue Reading Comparison of serious adverse events posted at ClinicalTrials.gov and published in corresponding journal articles

Terminated trials in the ClinicalTrials.gov results database: reasons for termination and availability of results

A study published in PLOS ONE last week attempted to characterise the reasons why trials (listed on http://www.clinicaltrials.gov) were terminated, and also examined the availability of results from these trials. … Continue Reading Terminated trials in the ClinicalTrials.gov results database: reasons for termination and availability of results

Evidence-informed recommendations to reduce dissemination bias in clinical research: conclusions from the OPEN project

The aims of the OPEN project (http://www.open-project.eu) are to assess the current evidence on publication bias and to describe current practices by various key groups involved in funding, conducting and … Continue Reading Evidence-informed recommendations to reduce dissemination bias in clinical research: conclusions from the OPEN project